Another Egg Study

Roger Zoul · Joined: 17 Aug 2007 Posts: 4659

Title: Eggs modulate the inflammatory response to carbohydrate restricted
diets in overweight men

http://www.nutritionandmetabolism.com/content/5/1/6

Background
Carbohydrate restricted diets (CRD) consistently lower glucose and insulin
levels and improve atherogenic dyslipidemia [decreasing triglycerides and
increasing HDL cholesterol (HDL-C)]. We have previously shown that male
subjects following a CRD experienced significant increases in HDL-C only if
they were consuming a higher intake of cholesterol provided by eggs compared
to those individuals who were taking lower concentrations of dietary
cholesterol. Here, as a follow up of our previous study, we examined the
effects of eggs (a source of both dietary cholesterol and lutein) on
adiponectin, a marker of insulin sensitivity, and on inflammatory markers in
the context of a CRD.

Methods
Twenty eight overweight men [body mass index (BMI) 26-37 kg/m2] aged 40-70 y
consumed an ad libitum CRD (% energy from CHO:fat:protein = 17:57:26) for 12
wk. Subjects were matched by age and BMI and randomly assigned to consume
eggs (EGG, n=15) (640 mg additional cholesterol/day provided by eggs) or
placebo (SUB, n=13) (no additional dietary cholesterol). Fasting blood
samples were drawn before and after the intervention to assess plasma
lipids, insulin, adiponectin and markers of inflammation including
C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-I+/-),
interleukin-8 (IL- Cool

, monocyte chemoattractant protein-1 (MCP-1),
intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion
molecule-1(VCAM-1).

Results
Body weight, percent total body fat and trunk fat were reduced for all
subjects after 12 wk (P < 0.0001). Increases in adiponectin were also
observed (P < 0.01). Subjects in the EGG group had a 21% increase in this
adipokine compared to a 7% increase in the SUB group (P < 0.05). Plasma CRP
was significantly decreased only in the EGG group (P < 0.05). MCP-1 levels
were decreased for the SUB group (P< 0.001), but unchanged in the EGG group.
VCAM-1, ICAM-1, TNF-alpha and IL-8 were not modified by CRD or eggs.

Conclusions
A CRD with daily intake of eggs decreased plasma CRP and increased plasma
adiponectin compared to a CRD without eggs. These findings indicate that
eggs make a significant contribution to the anti-inflammatory effects of
CRD, possibly due to the presence of cholesterol, which increases HDL-C and
to the antioxidant lutein which modulates certain inflammatory responses.

Archived from group: alt>support>diet>low-carb

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 21, 4:54 am, "Roger Zoul" wrote:
> Title: Eggs modulate the inflammatory response to carbohydrate restricted
> diets in overweight men
>
> http://www.nutritionandmetabolism.com/content/5/1/6
>
> Background
> We have previously shown that male
> subjects following a CRD experienced significant increases in HDL-C only if
> they were consuming a higher intake of cholesterol provided by eggs compared
> to those individuals who were taking lower concentrations of dietary
> cholesterol.

I did not know that.

> Methods
> Subjects were matched by age and BMI and randomly assigned to consume
> eggs (EGG, n=15) (640 mg additional cholesterol/day provided by eggs) or
> placebo (SUB, n=13) (no additional dietary cholesterol).

Any ideas on what a placebo egg is? Maybe smart beaters or whatever
they
call those cholesterol free egg substitutes?

Thanks for the link Rog. I'm gonna go have some eggs in about an hour
or so.

Aaron Baugher · Joined: 17 Aug 2007 Posts: 492

"Roger Zoul" writes:

> Title: Eggs modulate the inflammatory response to carbohydrate
> restricted diets in overweight men

I just had five eggs this morning. Yay! Farm-fresh, local eggs too;
less than a week old. Yum. Not exactly pasture-raised--there's not
much pasture in Illinois in February--but the yolks are still a much
deeper orange than store-bought eggs, showing the chickens are finding
more than grain to eat.

--
Aaron -- 285/253/200 -- aaron.baugher.biz

Doug Freyburger · Joined: 17 Aug 2007 Posts: 168

Hollywood wrote:
> "Roger Zoul" wrote:
>
> > Title: Eggs modulate the inflammatory response to carbohydrate restricted
> > diets in overweight men
>
> >http://www.nutritionandmetabolism.com/content/5/1/6
>
> > Background
> > We have previously shown that male
> > subjects following a CRD experienced significant increases in HDL-C only if
> > they were consuming a higher intake of cholesterol provided by eggs compared
> > to those individuals who were taking lower concentrations of dietary
> > cholesterol.
>
> I did not know that.

But is it necessarily the dietary cholesterol in the eggs that
matters?

> > Methods
> > Subjects were matched by age and BMI and randomly assigned to consume
> > eggs (EGG, n=15) (640 mg additional cholesterol/day provided by eggs) or
> > placebo (SUB, n=13) (no additional dietary cholesterol).
>
> Any ideas on what a placebo egg is? Maybe smart beaters or whatever
> they call those cholesterol free egg substitutes?

In particular I'm interested in the amino acid balance and fat content
of the substitute.

Eggs were called "Eggs, Nature's most nearly perfect food" for a
while because they had the best known amino acid balance of
any food that had been measured at the time. What if this effect
is from fixing a previously unknown amino acid deficiency? What
if it's from one of the types of fatty acid in the yolk? There are
other factors in an egg than cholesterol.

Cubit · Joined: 17 Aug 2007 Posts: 1725

"Roger Zoul" wrote in message @mid.individual.net...
> Title: Eggs modulate the inflammatory response to carbohydrate restricted
> diets in overweight men
>
> http://www.nutritionandmetabolism.com/content/5/1/6
>
> Background
> Carbohydrate restricted diets (CRD) consistently lower glucose and insulin
> levels and improve atherogenic dyslipidemia [decreasing triglycerides and
> increasing HDL cholesterol (HDL-C)]. We have previously shown that male
> subjects following a CRD experienced significant increases in HDL-C only
> if they were consuming a higher intake of cholesterol provided by eggs
> compared to those individuals who were taking lower concentrations of
> dietary cholesterol. Here, as a follow up of our previous study, we
> examined the effects of eggs (a source of both dietary cholesterol and
> lutein) on adiponectin, a marker of insulin sensitivity, and on
> inflammatory markers in the context of a CRD.
>
> Methods
> Twenty eight overweight men [body mass index (BMI) 26-37 kg/m2] aged 40-70
> y consumed an ad libitum CRD (% energy from CHO:fat:protein = 17:57:26)
> for 12 wk. Subjects were matched by age and BMI and randomly assigned to
> consume eggs (EGG, n=15) (640 mg additional cholesterol/day provided by
> eggs) or placebo (SUB, n=13) (no additional dietary cholesterol). Fasting
> blood samples were drawn before and after the intervention to assess
> plasma lipids, insulin, adiponectin and markers of inflammation including
> C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-I+/-),
> interleukin-8 (IL- Cool

, monocyte chemoattractant protein-1 (MCP-1),
> intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion
> molecule-1(VCAM-1).
>
> Results
> Body weight, percent total body fat and trunk fat were reduced for all
> subjects after 12 wk (P < 0.0001). Increases in adiponectin were also
> observed (P < 0.01). Subjects in the EGG group had a 21% increase in this
> adipokine compared to a 7% increase in the SUB group (P < 0.05). Plasma
> CRP was significantly decreased only in the EGG group (P < 0.05). MCP-1
> levels were decreased for the SUB group (P< 0.001), but unchanged in the
> EGG group. VCAM-1, ICAM-1, TNF-alpha and IL-8 were not modified by CRD or
> eggs.
>
> Conclusions
> A CRD with daily intake of eggs decreased plasma CRP and increased plasma
> adiponectin compared to a CRD without eggs. These findings indicate that
> eggs make a significant contribution to the anti-inflammatory effects of
> CRD, possibly due to the presence of cholesterol, which increases HDL-C
> and to the antioxidant lutein which modulates certain inflammatory
> responses.
>
>

Thanks for the post.

While most of the biochemistry here goes over my head, I think it is
probably improper to conclude that cholesterol is the key. Eggs have lots
of stuff in them. They may be right, of course.

It is too bad they do not say how many eggs the subjects got per day.

Wouldn't it be wild if the supplement stores started selling cholesterol
pills to prevent inflammation and thus heart disease!

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 21, 12:22 pm, "Cubit" wrote:
> It is too bad they do not say how many eggs the subjects got per day.

I backed it out.
640 mg cholesterol works out to about 3 large - extra large eggs.

Cubit · Joined: 17 Aug 2007 Posts: 1725

"Hollywood" wrote in message @t66g2000hsf.googlegroups.com...
> On Feb 21, 12:22 pm, "Cubit" wrote:
>> It is too bad they do not say how many eggs the subjects got per day.
>
> I backed it out.
> 640 mg cholesterol works out to about 3 large - extra large eggs.

Thank you.

I just checked Fitday. If dietary cholesterol is good, I'm in great shape.

My blood tests check a lot of things, but they don't seem to check for
inflammation, yet.

Hakan Lane · Joined: 21 Feb 2008 Posts: 3

Roger Zoul wrote:

> Title: Eggs modulate the inflammatory response to carbohydrate restricted
> diets in overweight men

What is this "inflammatory response"? I haven't experienced it as I can
think of, nor did I really read any "overweight man" switching to Atkins
claiming that he was struck by an inflammation. I would be glad to know
what it is.

--
Newsoffice.de - Die Onlinesoftware zum Lesen und Schreiben im Usenet
Die Signatur läßt sich nach Belieben anpassen Wink

Bob · Joined: 27 Jan 2008 Posts: 4

On Sat, 23 Feb 2008 15:51:34 -0500, Hakan Lane wrote:

>
> Roger Zoul wrote:
>
>> Title: Eggs modulate the inflammatory response to carbohydrate
>> restricted diets in overweight men
>
> What is this "inflammatory response"? I haven't experienced it as I can
> think of, nor did I really read any "overweight man" switching to Atkins
> claiming that he was struck by an inflammation. I would be glad to know
> what it is.
>
>

I think it's a scam and something used to sell studies.

--
Using Opera's revolutionary e-mail client: http://www.opera.com/mail/

Doug Freyburger · Joined: 17 Aug 2007 Posts: 168

Bob wrote:
> Hakan Lane wrote:
> > Roger Zoul wrote:
>
> >> Title: Eggs modulate the inflammatory response to carbohydrate
> >> restricted diets in overweight men
>
> > What is this "inflammatory response"? I haven't experienced it as I can
> > think of, nor did I really read any "overweight man" switching to Atkins
> > claiming that he was struck by an inflammation. I would be glad to know
> > what it is.

I wondered that as well. Very many people have reported reduced
swelling and that's a "response" toward the good. Not everyone
reports such, but many do.

> I think it's a scam and something used to sell studies.

Propaganda to get funding. Chuckle.

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