Study Details Link Between Obesity, Carbs and Esophageal Can

Jim · Joined: 31 Jan 2008 Posts: 29

> Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.

The headline is probably overstated.... there is a statistical
association here, not a cause and effect.

=====================================================

http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632

Study Details Link Between Obesity, Carbs and Esophageal Cancer

As Obesity and Carb-intake Rates Have Increased, So Has Specific Cancer

Cleveland, Ohio – February 25, 2008 – Cases of esophageal cancer
(adenocarcinoma) in the U.S. have risen in recent decades from 300,000
cases in 1973 to 2.1 million in 2001 at age-adjusted rates. A new study
published in The American Journal of Gastroenterology shows that these
rates in the U.S. closely mirrored trends of increased carbohydrate
intake and obesity from 1973-2001.

The study illustrates what may be a public heath concern as the
composition of U.S. diets changes and total carbohydrate and refined
carbohydrate intakes increase. Obesity is a risk factor for many types
of cancer, and a diet that includes a high percentage of calories from
refined carbohydrates is a common contributor to obesity. Carbohydrates
were also unique in that no other studied nutrients were found to
correlate with esophageal cancer rates.

The causes of esophageal cancer remain largely unknown. Despite recent
advances in treatment, esophageal cancer has a poor prognosis. The
five-year rate of survival for esophageal cancer remains below 20
percent and is the eighth-leading cause of cancer related death in
American men.

“If we can reverse the trends in refined carbohydrate intake and obesity
in the U.S., we may be able to reduce the incidence of esophageal
cancer,” says Dr. Li Li, senior author of the study.

_________________________________________________________________
This study is published in The American Journal of Gastroenterology.
Media wishing to receive a PDF of this article may contact
medicalnews@bos.blackwellpublishing.net.

Dr. Li Li is an Assistant Professor in the Department of Family Medicine
and Case Comprehensive Cancer Center at Case Western Reserve
University/University Hospitals Health System. Dr. Li can be reached for
questions at lxl62@cwru.edu.

The American Journal of Gastroenterology is the official publication of
the American College of Gastroenterology, and the #1 clinical journal in
gastroenterology. The journal brings a broad-based, interdisciplinary
approach to the study of gastroenterology, including articles reporting
on current observations, research results, methods of treatment, drugs,
epidemiology, and other topics relevant to clinical gastroenterology.
For more information, please visit www.blackwellpublishing.com/ajg.

The American College of Gastroenterology (ACG) was founded in 1932 to
advance the scientific study and medical practice of diseases of the
gastrointestinal (GI) tract. The College promotes the highest standards
in medical education and is guided by its commitment to meeting the
individual and collective needs of clinical GI practitioners. For more
information, please visit www.acg.gi.org.

=================================================

Abstract and link to full text below, for those who have managed to read
this far.

=================================================
http://www.amjgastro.com/showContent.asp?DID=3&SessionGUID=3D4369F0-3B7F-46F4-921C-5402F4C35659&id=ajg_1613_onearly112007&type=abstract

Carbohydrate Consumption and Esophageal Cancer:An Ecological Assessment

Cheryl L. Thompson, Ph.D. 1,2, Vijay Khiani, M.D. 3, Amitabh Chak,
M.D. 3, Nathan A. Berger, M.D. 3, and Li Li, M.D., Ph.D. 1,2

Affiliations
1Departments of Family Medicine
2Epidemiology and Biostatistics
3Medicine, Transdisciplinary Research on Energetics and Cancer
Program, Case Comprehensive Cancer Center, Case Western Reserve
University and University Hospitals of Cleveland, Cleveland, Ohio

OBJECTIVES: The incidence of esophageal adenocarcinoma is on the
rise in the United States. In this ecological study using the
Surveillance, Epidemiology, and End Results (SEER) program (1973–2001)
and national food consumption data (1909–1997), we evaluated the
correlation between secular trends of dietary macronutrient intakes and
esophageal cancer rates.

METHODS: Linear regressions were performed to assess the
correlation between age-adjusted incidence rates of esophageal cancers
and nutrients.

RESULTS: The increase in esophageal adenocarcinoma was found to be
strongly correlated with the rise in carbohydrate intake (P < 0.0001).
The decline in squamous cell carcinoma rates was negatively correlated
with carbohydrate intake in the univariate model (P < 0.0001), but this
correlation disappeared when adjusted for other nutrients. Correlations
of esophageal adenocarcinoma to percentage of calories from corn syrup,
representing refined carbohydrates, were statistically significant in
the univariate model (P < 0.0001), but decreased in significance in the
multivariate model (P = 0.0118). We also found a significant correlation
between obesity and esophageal adenocarcinoma (P < 0.0001) during the
same time period.

CONCLUSION: Our ecological evaluation suggests that high
carbohydrate intake and obesity can account for at least some of the
rise in esophageal adenocarcinoma. Within-population studies are needed
to clarify these trends.

(Am J Gastroenterol 2007;102:1-7)

Archived from group: alt>support>diet>low-carb

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 26, 7:56 am, Jim wrote:
> > Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.
>
> The headline is probably overstated.... there is a statistical
> association here, not a cause and effect.
>
> =====================================================
>
> http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632

Hrm. Let's see if we can come up with a causative story. Just there
is correlation doesn't mean there ISN'T causation.

When I eat too many carbs, I, like many people, get vary degrees
of acid reflux. We might prove this one by looking at sales of
antacids and acid blockers against carb consumption, but from
my own experience (and the related clinical experience of Dr.
Atkins and the Eadeses), we're pretty sure about this. Carbs
cause acid reflux.

Stomach acid where it doesn't belong cannot be a good thing.
It hurts. But could it be doing damage, effectively diverting the
immune system from fighting newlyn tumors?

I'm not disagreeing about the headline probably being over
stated, but at the same time, it's pretty easy to see how it
might work.

Jim · Joined: 31 Jan 2008 Posts: 29

Hollywood wrote:
> On Feb 26, 7:56 am, Jim wrote:
>>> Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.
>> The headline is probably overstated.... there is a statistical
>> association here, not a cause and effect.
>>
>> =====================================================
>>
>> http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632
>
> Hrm. Let's see if we can come up with a causative story. Just there
> is correlation doesn't mean there ISN'T causation.
>
> When I eat too many carbs, I, like many people, get vary degrees
> of acid reflux. We might prove this one by looking at sales of
> antacids and acid blockers against carb consumption, but from
> my own experience (and the related clinical experience of Dr.
> Atkins and the Eadeses), we're pretty sure about this. Carbs
> cause acid reflux.
>
> Stomach acid where it doesn't belong cannot be a good thing.
> It hurts. But could it be doing damage, effectively diverting the
> immune system from fighting newlyn tumors?
>
> I'm not disagreeing about the headline probably being over
> stated, but at the same time, it's pretty easy to see how it
> might work.
>

So, you elect to add an unsubstantiated hypothesis for "clarification"
purposes.

Did you read the actual abstract as published by the study authors?

Or did you manage to just read the PR Press Release issued by the
publishers nearly 60 days after the actual publication?

I enjoy your "mastermind" at work.

Did you ever apologize to the other poster about the McDonald's dish
that you insisted wasn't there anymore?

I thought so.

Marengo · Joined: 21 Jan 2008 Posts: 11

On Tue, 26 Feb 2008 07:56:12 -0600, Jim
wrote:

>> Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.

>The headline is probably overstated.... there is a statistical
>association here, not a cause and effect.

I doubt at all that it's overstated.

I had chronic heartburn and severe acid reflux for most of my adult
life. I ate Rolaids like candy, then took Zantac once or twice a day
when it came out. I still had reflux, and would often wake up in the
night gagging on my own vomit, Within days after I started my low
carb way of eating, the heartburn disappeared. Within a few weeks,
the acid reflux had completely gone away. It's been probably two years
now since I had heartburn, and that was only when I went off my LC WOE
for a day or ate something carby that I shouldn't have. And there is
not question that acid reflux is the main cause of esophageal cancer.
No, I don't think the headline is overstated at all! I'm ore
surprised that someone hasn't pointed this out sooner.

>Cleveland, Ohio – February 25, 2008 – Cases of esophageal cancer
>(adenocarcinoma) in the U.S. have risen in recent decades from 300,000
>cases in 1973 to 2.1 million in 2001 at age-adjusted rates. A new study
>published in The American Journal of Gastroenterology shows that these
>rates in the U.S. closely mirrored trends of increased carbohydrate
>intake and obesity from 1973-2001.
---
Peter
270/227/180

Marengo · Joined: 21 Jan 2008 Posts: 11

On Tue, 26 Feb 2008 09:35:22 -0600, Jim
wrote:

>Hollywood wrote:
>> On Feb 26, 7:56 am, Jim wrote:
>>>> Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.
>>> The headline is probably overstated.... there is a statistical
>>> association here, not a cause and effect.
>>>
>>> =====================================================
>>>
>>> http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632
>>
>> Hrm. Let's see if we can come up with a causative story. Just there
>> is correlation doesn't mean there ISN'T causation.

>> When I eat too many carbs, I, like many people, get vary degrees
>> of acid reflux. We might prove this one by looking at sales of
>> antacids and acid blockers against carb consumption, but from
>> my own experience (and the related clinical experience of Dr.
>> Atkins and the Eadeses), we're pretty sure about this. Carbs
>> cause acid reflux.
>>
>> Stomach acid where it doesn't belong cannot be a good thing.
>> It hurts. But could it be doing damage, effectively diverting the
>> immune system from fighting newlyn tumors?
>>
>> I'm not disagreeing about the headline probably being over
>> stated, but at the same time, it's pretty easy to see how it
>> might work.

>So, you elect to add an unsubstantiated hypothesis for "clarification"
>purposes.

"Unsubstantiated?" You're idiotic. You're talking stupidly about
something of which you apparently have no knowledge at all -- without
even doing basic research to verify your dumb statements.

>Did you read the actual abstract as published by the study authors?
>
>Or did you manage to just read the PR Press Release issued by the
>publishers nearly 60 days after the actual publication?

Um, it's *you* who are talking out your substantial butt.
Chronic acid reflux has long been known to be a major cause of
esophageal cancer, and excess carbs cause acid reflux.

http://medicineworld.org/cancer/lead/8-2006/how-acid-reflux-leads-to-esophageal-cancer.html

http://www.mayoclinic.com/health/esophageal-cancer/DS00500/DSECTION=3

http://www.newswise.com/articles/view/531123/

http://www.medicalnewstoday.com/articles/49864.php

http://www.suite101.com/article.cfm/new_cancer_treatments/103693

http://www.webmd.com/cancer/news/20051110/acid-reflux-linked-to-esophageal-cancer

---
Peter
270/227/180

Roger Zoul · Joined: 17 Aug 2007 Posts: 4659

"Marengo" wrote
> wrote:
>
>>> Esophageal cancer rates in the U.S. closely mirrored trends of increased
>>> carbohydrate intake and obesity from 1973-2001.
>
>>The headline is probably overstated.... there is a statistical
>>association here, not a cause and effect.
>
> I doubt at all that it's overstated.
>
> I had chronic heartburn and severe acid reflux for most of my adult
> life. I ate Rolaids like candy, then took Zantac once or twice a day
> when it came out. I still had reflux, and would often wake up in the
> night gagging on my own vomit, Within days after I started my low
> carb way of eating, the heartburn disappeared. Within a few weeks,
> the acid reflux had completely gone away. It's been probably two years
> now since I had heartburn, and that was only when I went off my LC WOE
> for a day or ate something carby that I shouldn't have. And there is
> not question that acid reflux is the main cause of esophageal cancer.
> No, I don't think the headline is overstated at all! I'm ore
> surprised that someone hasn't pointed this out sooner.

I had a similar experience which was cured (or controlled) by LC. That
reflux will definitely mess you up.

MoiMoi · Joined: 17 Aug 2007 Posts: 5

In article , rogerzoul2@hotmail.com
says...
>
> "Marengo" wrote
> > wrote:
> >
> >>> Esophageal cancer rates in the U.S. closely mirrored trends of increased
> >>> carbohydrate intake and obesity from 1973-2001.
> >
> >>The headline is probably overstated.... there is a statistical
> >>association here, not a cause and effect.
> >
> > I doubt at all that it's overstated.
> >
> > I had chronic heartburn and severe acid reflux for most of my adult
> > life. I ate Rolaids like candy, then took Zantac once or twice a day
> > when it came out. I still had reflux, and would often wake up in the
> > night gagging on my own vomit, Within days after I started my low
> > carb way of eating, the heartburn disappeared. Within a few weeks,
> > the acid reflux had completely gone away. It's been probably two years
> > now since I had heartburn, and that was only when I went off my LC WOE
> > for a day or ate something carby that I shouldn't have. And there is
> > not question that acid reflux is the main cause of esophageal cancer.
> > No, I don't think the headline is overstated at all! I'm ore
> > surprised that someone hasn't pointed this out sooner.
>
> I had a similar experience which was cured (or controlled) by LC. That
> reflux will definitely mess you up.

Yep, my reflux gone within days of doing Atkins induction level, several
years ago.

MM

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 26, 9:35 am, Jim wrote:
> Hollywood wrote:
> > On Feb 26, 7:56 am, Jim wrote:
> >>> Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.
> >> The headline is probably overstated.... there is a statistical
> >> association here, not a cause and effect.
>
> >> =====================================================
>
> >>http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632
>
> > Hrm. Let's see if we can come up with a causative story. Just there
> > is correlation doesn't mean there ISN'T causation.
>
> > When I eat too many carbs, I, like many people, get vary degrees
> > of acid reflux. We might prove this one by looking at sales of
> > antacids and acid blockers against carb consumption, but from
> > my own experience (and the related clinical experience of Dr.
> > Atkins and the Eadeses), we're pretty sure about this. Carbs
> > cause acid reflux.
>
> > Stomach acid where it doesn't belong cannot be a good thing.
> > It hurts. But could it be doing damage, effectively diverting the
> > immune system from fighting newlyn tumors?
>
> > I'm not disagreeing about the headline probably being over
> > stated, but at the same time, it's pretty easy to see how it
> > might work.
>
> So, you elect to add an unsubstantiated hypothesis for "clarification"
> purposes.

Different methodology at work, Jim. I forgot to add the usual thank
you
for the study. I always find them interesting. But, back to the matter
at hand. You like to look at the studies. I like to try and understand
the world. Understanding means putting forth hypotheses. They all
start unsubstantiated. Then they get tested and disproved. My
"unsubstantiated hypothesis" would be a useful avenue for further
study by these folks. So, they found a correlation. Next, look for
causation. Maybe you need to brush up on your scientific method
and your study design.

> Did you read the actual abstract as published by the study authors?

I read what you posted.

> Or did you manage to just read the PR Press Release issued by the
> publishers nearly 60 days after the actual publication?

I read what you posted.

> I enjoy your "mastermind" at work.

I'm glad you do.
> Did you ever apologize to the other poster about the McDonald's dish
> that you insisted wasn't there anymore?

WTF are you talking about? Link please.

> I thought so.

And you are always right, so never have to apologize. To avoid
further confusion, you should probably change your posting name to
"Perfect Jim." For the love of God.

PS- Keep the studies coming. The interpretation too. I like you. No
sarcasm.

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 26, 8:24 pm, MoiMoi wrote:
> In article , rogerzo...@hotmail.com
> says...
>
>
>
>
>
> > "Marengo" wrote
> > > wrote:
>
> > >>> Esophageal cancer rates in the U.S. closely mirrored trends of increased
> > >>> carbohydrate intake and obesity from 1973-2001.
>
> > >>The headline is probably overstated.... there is a statistical
> > >>association here, not a cause and effect.
>
> > > I doubt at all that it's overstated.
>
> > > I had chronic heartburn and severe acid reflux for most of my adult
> > > life. I ate Rolaids like candy, then took Zantac once or twice a day
> > > when it came out. I still had reflux, and would often wake up in the
> > > night gagging on my own vomit, Within days after I started my low
> > > carb way of eating, the heartburn disappeared. Within a few weeks,
> > > the acid reflux had completely gone away. It's been probably two years
> > > now since I had heartburn, and that was only when I went off my LC WOE
> > > for a day or ate something carby that I shouldn't have. And there is
> > > not question that acid reflux is the main cause of esophageal cancer.
> > > No, I don't think the headline is overstated at all! I'm ore
> > > surprised that someone hasn't pointed this out sooner.
>
> > I had a similar experience which was cured (or controlled) by LC. That
> > reflux will definitely mess you up.
>
> Yep, my reflux gone within days of doing Atkins induction level, several
> years ago.
>
> MM

I'm going to add to that. Reading Marengo on it is like my story, if
he were
younger and less far along the path. Sub Tums with whatever Acid
Blocker
they come with in the big bottle, and that was my candy. On top of the
other
candy.

Hollywood · Joined: 17 Aug 2007 Posts: 132

On Feb 26, 9:35 am, Jim wrote:
> Hollywood wrote:
> Did you ever apologize to the other poster about the McDonald's dish
> that you insisted wasn't there anymore?

No need for the link. I figured out what you were talking about. It is
me
who deserves your apology. The OP and I were talking about a company
that was once owned by McDonalds.
http://www.chipotle.com/
(requires flash)

You mistakenly thought we were talking about a menu item. Go back
to that thread, as the full explanation is there.

> I thought so.

When YOU apologize to ME for:
1- The other thread where you have wronged me through your own
misunderstanding
and
2- This thread, where Marengo has countered your vicious attack
on me with more studies demonstrating the logic chain between
obesity, carbs, reflux, and cancer (which I had actually picked up
from Mike Eades Blog I dunno when, so didn't have the studies,
just the understanding).

At that point, all is square. Till then, you're in the wrong.
Sorry.

Roger Zoul · Joined: 17 Aug 2007 Posts: 4659

"Hollywood" wrote in message @p25g2000hsf.googlegroups.com...
> On Feb 26, 9:35 am, Jim wrote:
>> Hollywood wrote:
>> > On Feb 26, 7:56 am, Jim wrote:
>> >>> Esophageal cancer rates in the U.S. closely mirrored trends of
>> >>> increased carbohydrate intake and obesity from 1973-2001.
>> >> The headline is probably overstated.... there is a statistical
>> >> association here, not a cause and effect.
>>
>> >> =====================================================
>>
>> >>http://www.blackwellpublishing.com/press/pressitem.asp?ref=1632
>>
>> > Hrm. Let's see if we can come up with a causative story. Just there
>> > is correlation doesn't mean there ISN'T causation.
>>
>> > When I eat too many carbs, I, like many people, get vary degrees
>> > of acid reflux. We might prove this one by looking at sales of
>> > antacids and acid blockers against carb consumption, but from
>> > my own experience (and the related clinical experience of Dr.
>> > Atkins and the Eadeses), we're pretty sure about this. Carbs
>> > cause acid reflux.
>>
>> > Stomach acid where it doesn't belong cannot be a good thing.
>> > It hurts. But could it be doing damage, effectively diverting the
>> > immune system from fighting newlyn tumors?
>>
>> > I'm not disagreeing about the headline probably being over
>> > stated, but at the same time, it's pretty easy to see how it
>> > might work.

Hollywood - I liked your comments. I'm not sure why a hypothesis has to
have any particular substantiation, but I do think yours has some. Perhaps
if you were expecting someone to pay you to do a study, then you're need to
provide that substantiation. In this forum just shared experience is
sufficient, IMO.

>>
>> So, you elect to add an unsubstantiated hypothesis for "clarification"
>> purposes.
>
> Different methodology at work, Jim. I forgot to add the usual thank
> you
> for the study. I always find them interesting. But, back to the matter
> at hand. You like to look at the studies. I like to try and understand
> the world. Understanding means putting forth hypotheses. They all
> start unsubstantiated. Then they get tested and disproved. My
> "unsubstantiated hypothesis" would be a useful avenue for further
> study by these folks. So, they found a correlation. Next, look for
> causation. Maybe you need to brush up on your scientific method
> and your study design.
>
>> Did you read the actual abstract as published by the study authors?
>
> I read what you posted.
>
>> Or did you manage to just read the PR Press Release issued by the
>> publishers nearly 60 days after the actual publication?
>
> I read what you posted.
>
>> I enjoy your "mastermind" at work.
>
> I'm glad you do.
>> Did you ever apologize to the other poster about the McDonald's dish
>> that you insisted wasn't there anymore?
>
> WTF are you talking about? Link please.
>
>> I thought so.
>
> And you are always right, so never have to apologize. To avoid
> further confusion, you should probably change your posting name to
> "Perfect Jim." For the love of God.
>
> PS- Keep the studies coming. The interpretation too. I like you. No
> sarcasm.

Jo Anne · Joined: 17 Aug 2007 Posts: 38

On Wed, 27 Feb 2008 05:45:37 -0800 (PST), Hollywood
wrote:

>On Feb 26, 8:24 pm, MoiMoi wrote:
>> In article , rogerzo...@hotmail.com
>> says...

>> > "Marengo" wrote
>> > > wrote:
>>
>> > >>> Esophageal cancer rates in the U.S. closely mirrored trends of increased
>> > >>> carbohydrate intake and obesity from 1973-2001.
>>
>> > >>The headline is probably overstated.... there is a statistical
>> > >>association here, not a cause and effect.
>>
>> > > I doubt at all that it's overstated.
>>
>> > > I had chronic heartburn and severe acid reflux for most of my adult
>> > > life. I ate Rolaids like candy, then took Zantac once or twice a day
>> > > when it came out. I still had reflux, and would often wake up in the
>> > > night gagging on my own vomit, Within days after I started my low
>> > > carb way of eating, the heartburn disappeared. Within a few weeks,
>> > > the acid reflux had completely gone away. It's been probably two years
>> > > now since I had heartburn, and that was only when I went off my LC WOE
>> > > for a day or ate something carby that I shouldn't have. And there is
>> > > not question that acid reflux is the main cause of esophageal cancer.
>> > > No, I don't think the headline is overstated at all! I'm ore
>> > > surprised that someone hasn't pointed this out sooner.
>>
>> > I had a similar experience which was cured (or controlled) by LC. That
>> > reflux will definitely mess you up.
>>
>> Yep, my reflux gone within days of doing Atkins induction level, several
>> years ago.
>>
>> MM
>
>I'm going to add to that. Reading Marengo on it is like my story, if
>he were
>younger and less far along the path. Sub Tums with whatever Acid
>Blocker
>they come with in the big bottle, and that was my candy. On top of the
>other
>candy.

Me three. My drug of choice was Pepcid Complete. I used to panic if I
didn't have a package of them in my purse.

In addition to the heartburn and reflux, I also used to have fairly
frequent esophageal spasms. Anyone who has had one knows what they
are. Felt rather like what I imagine a heart attack would feel like. I
could get rid of the pain by taking a Pepcid Complete and sipping ice
water for 10 minutes or so.

Like everyone else, this was all history about a week after I started
low-carbing. The only time I have heartburn any more is when I eat
bread.

Jo Anne

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